Histamine induced high mobility group box-1 release from vascular endothelial cells through H1 receptor
BackgroundSystemic allergic reaction is characterized by vasodilation and vascular leakage, which causes a rapid, precipitous and sustained decrease in arterial blood pressure with a concomitant decrease of cardiac output.Histamine is a Switch major mediator released by mast cells in allergic inflammation and response.It causes a cascade of inflamm